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WELCOME

My name is Ashley Ingiosi, and I am a BRAIN Initiative K99/R00 investigator & Ruth L. Kirschstein  postdoctoral fellow in the laboratory of Marcos Frank, PhD at Washington State University in Spokane. My current research focuses on the role of astrocytes in sleep and sleep homeostasis. I will continue this research as an Assistant Professor in the Department of Neuroscience at The Ohio State University beginning Fall 2022.

Interests

  • Sleep & Sleep Homeostasis

  • Astrocytes

  • Neuronal-glial interactions

  • Neuroinflammation

  • In vivo imaging

  • Autism

Education

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​PhD in Neuroscience, 2015

University of Michigan

​BS in Biopsychology & Cognitive Science and General Biology, 2006

University of Michigan​

A role for astroglial calcium in mammalian sleep and sleep regulation

Ingiosi AM, Hayworth CR, Harvey DO, Singletary KG, Rempe MJ, Wisor JP, Frank MG (2020) Current Biology 30:4373-4383.e7

Video shows astrocyte activity in the brain during non-rapid eye movement sleep (NREMS), rapid eye movement sleep (REMS) and wakefulness (WAKE) as captured with a genetically encoded calcium indicator and miniscope. Video shown is 16x faster than normal speed.
A quick discussion of our main findings can be found here.

News &

Announcements

Howard Hughes Medical Institute scholarship recipient for The Jackson Laboratory Impacts of Sleep and Circadian Biology on Alzheimer’s Disease and Aging workshop
Scholarship recipient for the American Academy of Sleep Medicine Foundation Young Investigators Research Forum 2021 cohort
Our study exploring the role of astroglial modulation of sleep expression and homeostasis via noradrenergic signaling is published in Clocks & Sleep.
A quick discussion of our main findings can be found here.
Our review on the latest research on astroglial contributions to sleep and sleep homeostasis is in press at The FEBS Journal.
The Ingiosi Lab will open in Fall 2022 in the Department of Neuroscience at The Ohio State University!!!
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Graphical abstract from Goodnight, astrocyte: waking up to astroglial mechanisms in sleep, The FEBS Journal.

Recent & Upcoming Presentations

Sleeping under the stars: astrocyte contributions to sleep
June 21, 2022
Researcher Sleep and the Brain series (Invited)
Basal forebrain astrocytes promote sustained wakefulness through Gq-protein-coupled pathways
October & November 2021
Poster at The Jackson Laboratory Impacts of Sleep and Circadian Biology on Alzheimer’s Disease and Aging workshop & Neuroscience 2021
Sleeping under the stars: astrocyte contributions to sleep
August 12, 2021
William C. Dement Sleep and Chronobiology Summer Research Apprenticeship Retreat Colloquium, Providence, RI (Invited)
Star light, star bright: considerations for imaging astrocyte dynamics
March 17, 2021
Inscopix INSPIRE Webinar Series (Invited)
- About the cover image -
A pseudocolored max projection image of astrocytes expressing a genetically encoded calcium indicator in vivo (unpublished). Not to be shared without permission.